LCS SPIM-Light Sheet Microscope

Product Overview

The LCS SPIM is the latest product in Luxendo’s growing family of light-sheet microscopes. The basic configuration of the Luxendo LCS offers a cost-effective solution for cleared sample imaging. Based on a very versatile layout, the highly flexible upgrade options expand the performance of the system to increase speed and optical performance.

A quartz crystal cuvette, available in different lengths, facilitates mounting of large, delicate samples. The specimen is simply introduced into the cuvette filled with the clearing solution. The motorized sample stage for positioning and stack acquisition as well as the programmable optics concept for fast 3D scanning of the light-sheet through the sample ensure that the sample remains unperturbed during the imaging experiment while achieving the highest acquisition speed.

Typical applications of the microscope include imaging of large cleared-tissue samples, e.g. whole mouse brains to visualize complete neuronal and vascular networks. Microscopy of cleared organs or thick tissue samples is highly relevant in developmental biology studies and for cancer research, e.g. when investigating organ development, tumor structure and tumorigenesis.

Sample Chamber 

Sample mounting

An exchangeable quartz-crystal cuvette simplifies the whole sample mounting procedure as well as cleaning and maintenance, while ensuring compatibility with a wide range of clearing solutions by covering a refractive-index (RI) range from 1.33 to 1.57.

The cuvette is available in different lengths to accommodate samples of different sizes: the maximum cuvette dimensions are 40 mm × 20 mm × 20 mm (l × w × h).

Sample Clearing

Exchangeable chamber

Device Design

The LCS SPIM's compact, robust and vibration-free design provides maximal stability even during long-term high-throughput experiments.

Tailored to fit your lab bench, this class 1 laser system does not require any air table or vibration-compensation mechanism as all moving components are light-weight and balanced. Maximal stability of focus and thermal conditions are also guaranteed. The proprietary piezo-crawler stages ensure longevity and precision for a permanently accurate specimen positioning. Neither the images nor the quality of your sample are affected thanks to the unique and very gentle image-acquisition concept.

Fast imaging mode 

The basic configuration of the LCS SPIM can be upgraded with axial illumination scanning to extend the field of view (FOV) and to reduce shadowing effects. 

Fast imaging mode

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